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Zinc Pyrithione although the exact mechanism of action of the "activated" zinc pyrithione preparation is unknown it may be speculated that the possible anti-proliferative mechanism of action of zinc pyrithione may involve the regulation of DNA transcription factors containing "zinc finger" binding domains.(9,10) It is also well recognized that many enzymes require the binding of metal ions for activation. Perhaps one of these (zinc requiring) enzymes or transcription factors plays a key role in the regulation of cellular proliferation. It is also well known that a deficiency of zinc produces a disease state (acrodermatitis enteropathica) that includes psoriasiform lesions (11,12). Perhaps the vehicle or the activated form of zinc pyrithione permits a physiologic level of zinc to be reached in the target cells, either epidermal and/or lymphocytic. The combination of zinc pyrithione with the other vehicle including isopropyl myristate may also have significant additional influence on clinical effectiveness..
Zinc pyrithione
is also used extensively in adhesive coatings for floorings and for fungal protection of carpet backing. It is registered with the U.S. Environmental Protection Agency as zinc OMADINE® fungicide by Arch for applications such as dry-film preservation of architectural and industrial paints and coatings, as well as adhesives, sealants and grouts. Zinc OMADINE® fungicide is available in standard and fine-particle, 48% aqueous-dispersion form with a negligible VOC content.

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Zinc pyrithione is also known as zinc 2-pyridinethiol-n-oxide. It has a water solubility of 8 ppm at neutral pH. This low solubility makes the zinc pyrithione suitable for use in outdoor products that require protection against microorganisms, because it will not easily leach out of a paint film.

Zinc Pyrithione though still relatively new to the industry, has been well-received by the industry as both a fungicide and algaecide. During the last 10 years, the industry has not had many choices of new dry-film preservatives. However, zinc pyrithione actually is not a new fungicide -- it has been used for more than 30 years as the fungicide in anti dandruff shampoos and similar personal care products.

UV degradation of zinc pyrithione in a paint film is gradual, and therefore, efficacy in direct sunlight can be expected for years. Its stability at high temperatures is also very good -- zinc pyrithione can withstand temperatures of 100°C for at least 120 hours, with a decomposition temperature of 240°C. Another concern for fungicides in latex paints is alkaline stability.

The stability of zinc pyrithione is presently being studied at up to pH 11.0. After nine months at pH 11.0, a 0.5 % zinc pyrithione dispersion is still stable, and the study will continue.

Because pyrithione is an excellent chelating agent, zinc pyrithione cannot be used in paints that relies on metal carboxalates for film cure. The metal, particularly cobalt will transchelate with the zinc and lose the ability to catalyze the film curing. Also, in latex paints, if the water supply contains high concentrations of soluble iron, a sequestering agent should be used to preferentially chelate with the iron.

Since zinc pyrithione shows little tendency to yellow in paint films and does not cause acceleration of chalking or fading, the same fungicide can be used for both whites and colors. This reduces inventory and helps formulators avoid the inadvertent addition of the wrong fungicide to a batch of paint. Photo below illustrates the negligible effect zinc pyrithione has on the fading of a blue tint, acrylic latex paint when compared to a commonly used fungicide.

We present here a report of a case using a novel topical preparation of zinc pyrithione for the treatment of psoriasis. Topical zinc pyrithione appears to be a safe and effective treatment for psoriasis.

This report describes the use of a preparation containing zinc pyrithione (0.25%) in a vehicle containing isopropyl myristate to treat a case of psoriasis.

We have recently become aware of a new anti-psoriatic treatment containing zinc pyrithione (which is also recognized as the active ingredient in a major anti-dandruff shampoo). The effectiveness of zinc pyrithione to treat seborrheic dermatitis and psoriasis has been well documented (4,5,6,7,8,13). Since some believe that seborrheic dermatitis and psoriasis may lie on different ends of the same spectrum, it seemed reasonable to try a topical preparation of zinc pyrithione to treat psoriasis. The mechanism of action of zinc pyrithione on psoriasis and seborrheic dermatitis has been reported to be anti-proliferative via "DNA interactions", anti-yeast, antiseptic, and keratinolytic mechanisms.(4,5,6,8)

We report here the clinical results of a psoriatic patient treated with a topical spray containing zinc pyrithione.

A 39 year old man with a 14 year history of moderate plaque psoriasis was instructed to spray the topical zinc pyrithione preparation, twice per day, to the left elbow. The right elbow was to be used as a control and received no treatment of any kind during the trial. The treatment preparation contains zinc pyrithione (0.25%) in a vehicle containing isopropyl myristate.

zinc pyrithione preparation to the left elbow only. At the end of the 3 week treatment period the left (treated) elbow was essentially clear. The right (control) elbow remained virtually unchanged, if not slightly worse. The patient also reported a complete disappearance of pruritus approximately 3 days into treatment, on the zinc pyrithione preparation treated plaque only, that was sustained throughout the treatment period.

In this preliminary report, an aerosol preparation of zinc pyrithione (0.25%) in a vehicle containing isopropyl myristate appears to be a safe and effective treatment for psoriasis. Each ml of the liquid preparation will cover an area the size of a palm, approximately 6-8 times.

Because of the promising results in this case report and a plethora of anecdotal reports, we are initiating a 60 patient, double-blind, vehicle- controlled clinical study evaluating the use of topical zinc pyrithione for the treatment of psoriasis. If additional controlled research confirms these encouraging results, topical zinc pyrithione may represent one of the major advances n the treatment of psoriasis

At the four-week follow up, the combination of zinc pyrithione demonstrated great efficacy in all parameters. For erythema, zinc pyrithione propionate demonstrated a 50 percent improvement.

For hyperkeratosis, zinc pyrithione success rate as compared with generic. There was a slight improvement of 23 percent with negative control cream. For thickness, zinc pyrithione once again had the greatest improvement, 58 percent

We found zinc pyrithione more effective than generic.

There appears to be a synergistic effect associated with the combination of zinc pyrithione proliferation with the zinc and anti-inflammatory of anti-immune effect. Zinc has already been demonstrated to work in conditions such as seborrheic dermatitis in which epidermal cells proliferate.

Zinc pyrithione
Spray was created for the daily hygiene of skin with a tendency to various types of skin disorders including psoriasis, eczema, dermatitis, seborrhea, dandruff and other acute skin disorders.

It relieves itching and it eliminates the desquamation of the skin and the scalp, improving your skins appearance

Zinc pyrithione can be used on practically the whole body. In order to facilitate its application on the scalp, there is an additional, special applicator in the box of the product.
Certain areas of the body, such as the external ear, genital area and eye contours, are very sensitive. Therefore, spray the palm of your hand and apply the product with your hand on these sensitive areas.
Zinc pyrithione penetrates the skin faster and deeper, so the results also come faster. The Spray should be applied twice a day. We recommend to continue the treatment for one additional week once the symptoms have disappeared

Skin Cap

Zinc pyrithione is recommended specially in the cases where the skin is so affected that it shows itself very dry and chapped as well as for areas and cases where it is difficult to apply Zinc pyrithione.

More precisely we are talking about localized areas of the face, the external ear, the genital area and eye contours. Also we advise to use Zinc pyrithione instead of Zinc pyrithione in young children under ten years old, since their skin is very sensitive.

We recommend to begin the treatment of open wounds in the skin with Zinc pyrithione. (The Spray at this stage would cause irritation and soreness because of the alcohol and the gas of this product.)
Once the wound is closed, the treatment can be continued with Zinc pyrithione.
Also as hands are the most difficult area to treat, because by washing your hands you take off the medication, we advise you to use Zinc pyrithione after you wash your hands to keep the medication active.

Zinc pyrithione is indicated for the care of the scalp when it is affected by dandruff, dry seborrhea or fatty seborrhea. It moisturizes the skin in a natural way and eliminates the excess oily residue on the scalp cleaning the affected area.

Zinc pyrithione Shampoo also relieves itching, reduces flaking and helps to increase the healing power of the skin, it balances the activity of the scalp cells and has a positive influence on hair growth
Zinc pyrithione can be used together with Zinc pyrithione. When there are serious localized lesions in the scalp, we recommend to apply Zinc pyrithione on the localized lesions and use Zinc pyrithione as the only shampoo to wash your hair with normally.
Zinc pyrithione can be used during a long period of time without losing its effectiveness. (Other antidandruff shampoos with unactivated zinc pyrithione often lose their effectiveness completely after one or two months of use.)