Zinc Pyrithione although the exact mechanism of action of the "activated"
pyrithione preparation is unknown it may be speculated that the
possible anti-proliferative mechanism of action of zinc pyrithione
may involve the regulation of DNA transcription factors containing
"zinc finger" binding domains.(9,10) It is also well recognized that
many enzymes require the binding of metal ions for activation.
Perhaps one of these (zinc requiring) enzymes or transcription
factors plays a key role in the regulation of cellular
proliferation. It is also well known that a deficiency of zinc
produces a disease state (acrodermatitis enteropathica) that
includes psoriasiform lesions (11,12). Perhaps the vehicle or the
activated form of zinc pyrithione permits a physiologic level of
zinc to be reached in the target cells, either epidermal and/or
lymphocytic. The combination of zinc pyrithione with the other
vehicle including isopropyl myristate may also have significant
additional influence on clinical effectiveness..
Zinc pyrithione is also used extensively in adhesive coatings for
floorings and for fungal protection of carpet backing. It is
registered with the U.S. Environmental Protection Agency as zinc
OMADINE® fungicide by Arch for applications such as dry-film
preservation of architectural and industrial paints and coatings, as
well as adhesives, sealants and grouts. Zinc OMADINE® fungicide is
available in standard and fine-particle, 48% aqueous-dispersion form
with a negligible VOC content.
psoriasis treatment -
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Zinc pyrithione is also known as zinc 2-pyridinethiol-n-oxide. It
has a water solubility of 8 ppm at neutral pH. This low solubility
makes the zinc pyrithione suitable for use in outdoor products that
require protection against microorganisms, because it will not
easily leach out of a paint film.
Zinc Pyrithione though still relatively new to the industry, has
been well-received by the industry as both a fungicide and
algaecide. During the last 10 years, the industry has not had many
choices of new dry-film preservatives. However, zinc pyrithione
actually is not a new fungicide -- it has been used for more than 30
years as the fungicide in anti dandruff shampoos and similar
personal care products.
UV degradation of zinc pyrithione in a paint film is gradual, and
therefore, efficacy in direct sunlight can be expected for years.
Its stability at high temperatures is also very good -- zinc
pyrithione can withstand temperatures of 100°C for at least 120
hours, with a decomposition temperature of 240°C. Another concern
for fungicides in latex paints is alkaline stability.
The stability of zinc pyrithione is presently being studied at up
to pH 11.0. After nine months at pH 11.0, a 0.5 % zinc pyrithione
dispersion is still stable, and the study will continue.
Because pyrithione is an excellent chelating agent, zinc
pyrithione cannot be used in paints that relies on metal
carboxalates for film cure. The metal, particularly cobalt will
transchelate with the zinc and lose the ability to catalyze the film
curing. Also, in latex paints, if the water supply contains high
concentrations of soluble iron, a sequestering agent should be used
to preferentially chelate with the iron.
Since zinc pyrithione shows little tendency to yellow in paint
films and does not cause acceleration of chalking or fading, the
same fungicide can be used for both whites and colors. This reduces
inventory and helps formulators avoid the inadvertent addition of
the wrong fungicide to a batch of paint. Photo below
illustrates the negligible effect zinc pyrithione has on the fading
of a blue tint, acrylic latex paint when compared to a commonly used
We present here a report of a case using a novel topical
preparation of zinc pyrithione for the treatment of psoriasis.
Topical zinc pyrithione appears to be a safe and effective treatment
This report describes the use of a preparation containing zinc
pyrithione (0.25%) in a vehicle containing isopropyl myristate to
treat a case of psoriasis.
We have recently become aware of a new anti-psoriatic treatment
containing zinc pyrithione (which is also recognized as the active
ingredient in a major anti-dandruff shampoo). The effectiveness of
zinc pyrithione to treat seborrheic dermatitis and psoriasis has
been well documented (4,5,6,7,8,13). Since some believe that
seborrheic dermatitis and psoriasis may lie on different ends of the
same spectrum, it seemed reasonable to try a topical preparation of
zinc pyrithione to treat psoriasis. The mechanism of action of
pyrithione on psoriasis and seborrheic dermatitis has been reported
to be anti-proliferative via "DNA interactions", anti-yeast,
antiseptic, and keratinolytic mechanisms.(4,5,6,8)
We report here the clinical results of a psoriatic patient treated
with a topical spray containing zinc pyrithione.
A 39 year old man with a 14 year history of moderate plaque
psoriasis was instructed to spray the topical zinc pyrithione
preparation, twice per day, to the left elbow. The right elbow was
to be used as a control and received no treatment of any kind during
the trial. The treatment preparation contains zinc pyrithione
(0.25%) in a vehicle containing isopropyl myristate.
zinc pyrithione preparation to the left elbow only. At the end of
the 3 week treatment period the left (treated) elbow was essentially
clear. The right (control) elbow remained virtually unchanged, if
not slightly worse. The patient also reported a complete
disappearance of pruritus approximately 3 days into treatment, on
the zinc pyrithione preparation treated plaque only, that was
sustained throughout the treatment period.
In this preliminary report, an aerosol preparation of zinc
pyrithione (0.25%) in a vehicle containing isopropyl myristate
appears to be a safe and effective treatment for psoriasis. Each ml
of the liquid preparation will cover an area the size of a palm,
approximately 6-8 times.
Because of the promising results in this case report and a plethora
of anecdotal reports, we are initiating a 60 patient, double-blind,
vehicle- controlled clinical study evaluating the use of topical
zinc pyrithione for the treatment of psoriasis. If additional
controlled research confirms these encouraging results, topical zinc
pyrithione may represent one of the major advances n the treatment
At the four-week follow up, the combination of zinc pyrithione demonstrated great efficacy in all parameters. For
erythema, zinc pyrithione propionate demonstrated a 50 percent
For hyperkeratosis, zinc pyrithione success rate as compared with
generic. There was a slight improvement of 23 percent with negative
control cream. For thickness, zinc pyrithione once again had the
greatest improvement, 58 percent
We found zinc pyrithione more effective than generic.
There appears to be a synergistic effect associated with the
combination of zinc pyrithione proliferation with the zinc and anti-inflammatory
of anti-immune effect. Zinc has already been demonstrated to work in
conditions such as seborrheic dermatitis in which epidermal cells
Zinc pyrithione Spray was created for
the daily hygiene of skin with a tendency to various types of skin
disorders including psoriasis, eczema, dermatitis, seborrhea, dandruff
and other acute skin disorders.
It relieves itching and it eliminates the desquamation of the skin
and the scalp, improving your skins appearance
Zinc pyrithione can be used
on practically the whole body. In order to facilitate its application
on the scalp, there is an additional, special applicator in the
box of the product.
Certain areas of the body, such as the external ear, genital area
and eye contours, are very sensitive. Therefore, spray the palm
of your hand and apply the product with your hand on these sensitive
Zinc pyrithione penetrates the
skin faster and deeper, so the results also come faster. The Spray
should be applied twice a day. We recommend to continue the treatment
for one additional week once the symptoms have disappeared
Zinc pyrithione is recommended specially in
the cases where the skin is so affected that it shows itself very
dry and chapped as well as for areas and cases where it is difficult
to apply Zinc pyrithione.
More precisely we are talking about localized areas of the face,
the external ear, the genital area and eye contours. Also we advise
to use Zinc pyrithione instead of
Zinc pyrithione in young children
under ten years old, since their skin is very sensitive.
We recommend to begin the treatment of open wounds in the skin with
Zinc pyrithione. (The Spray
at this stage would cause irritation and soreness because of the
alcohol and the gas of this product.)
Once the wound is closed, the treatment can be continued with
Also as hands are the most difficult area to treat, because by
washing your hands you take off the medication, we advise you to use
Zinc pyrithione after you
wash your hands to keep the medication active.
Zinc pyrithione is indicated for the care of the scalp when it is affected
by dandruff, dry seborrhea or fatty seborrhea. It moisturizes the
skin in a natural way and eliminates the excess oily residue on
the scalp cleaning the affected area.
Zinc pyrithione Shampoo also relieves itching, reduces flaking and helps to increase
the healing power of the skin, it balances the activity of the scalp
cells and has a positive influence on hair growth
Zinc pyrithione can be used together with
Zinc pyrithione. When there are serious localized lesions in
the scalp, we recommend to apply Zinc pyrithione
on the localized lesions and use Zinc pyrithione as the only
shampoo to wash your hair with normally.
Zinc pyrithione can be used during a long period of time without losing
its effectiveness. (Other antidandruff shampoos with unactivated
zinc pyrithione often lose their effectiveness completely after
one or two months of use.)